Caprine arthritis encephalitis (CAE), commonly known as 'big knee', is caused by a lentivirus or 'slow' virus associated with nervous disorder (encephalomyelitis) in kids and slowly-developing disease syndromes in older goats. Symptoms can vary markedly between animals with most well managed goats showing no obvious clinical signs.

Contents include:

• The virus
• The disease
• Epidemiology
• Zoonotic risk
• CAE risk factors
• CAE control
• CAE certification